******************************************************************************** seismic sim ******************************************************************************** Purpose ================================================================================ ``seismic sim`` generates synthetic sequencing data for testing and benchmarking. It is a group of subcommands that simulate individual components of the pipeline (reference sequences, structures, mutation rates, reads) or complete datasets. Subcommands ================================================================================ Run ``seismic sim {subcommand} --help`` for each subcommand's full option list. ============= =================================================================== Subcommand Description ============= =================================================================== ``ref`` Simulate a random reference sequence ``fold`` Simulate an RNA secondary structure ``params`` Simulate mutation-rate parameters for clusters ``clusts`` Simulate cluster memberships for reads ``ends`` Simulate read end positions ``muts`` Simulate per-read, per-position mutations ``idmut`` Simulate IDmut batch output directly ``fastq`` Simulate a FASTQ file from a reference ``total`` Run a full end-to-end simulation ``abstract`` Simulate abstract mutational data ============= =================================================================== Quick example ================================================================================ Run a full end-to-end simulation:: seismic sim total --help See the auto-generated :doc:`/cli` for the full option list for each subcommand. See also ================================================================================ - :doc:`/use/workflow/idmut` — the step whose output ``sim idmut`` mimics - :doc:`/algos/index` — the underlying mutation models